PEDIL research spans epidemiology, data science, genomics, population health, One Health, and decision-support science. Our publications reflect both methodological innovation and applied research across human, animal, and environmental systems.
Featured Publications
Tracing FMDV Spread Across East and the Horn of Africa
Virus Evolution · 2025
Genomic and spatial analyses reveal patterns and dynamics of foot-and-mouth disease virus movement across a region where multiple viral lineages circulate.
Opportunities for machine learning to predict cross-neutralization in FMDV serotype O
PLOS Computational Biology · 2025
Machine-learning models connect viral genetic variation with cross-neutralization to support more data-driven assessment of vaccine–virus relationships.
Ecological & Evolutionary Dynamics of Multi-Strain Viruses
Nature Ecology & Evolution · 2022
An integrative framework explores how ecological and evolutionary processes interact to shape the coexistence and dynamics of genetically diverse viral strains.
Extreme Weather and Population-Level Disease Risk
Veterinary Microbiology · 2024
This study examines how extreme weather events are associated with the occurrence of major diseases in U.S. swine populations.
Human Behavior and the Challenge of Biosecurity
Transboundary and Emerging Diseases · 2026
Qualitative research identifies behavioral and operational barriers and opportunities influencing adoption of enhanced biosecurity practices in U.S. swine systems.
Socio-Ecological Drivers of Youth Vulnerability
Global Public Health · 2026
A population-health study examines the individual, household, and broader socio-ecological factors associated with street-connectedness among children and youth in Namibia.
Browse by Research Area
Anticipatory epidemiology & precision health
Forecasting, early warning, predictive surveillance, environmental risk, and decision-support analytics.
Representative publications:
Weathering the storm: extreme weather events and their association with PED and PRRS occurrence
Veterinary Microbiology, 2024
Links environmental extremes with population-level disease occurrence and fits the predictive-risk side of PEDIL especially well.
Optimizing risk-based disease control strategies through network analysis: Case insights from FMD in Sri Lanka
Preventive Veterinary Medicine, 2025
Demonstrates how network analysis can support targeted, risk-based intervention.
Synergizing human and animal health surveillance systems: A time series analysis of brucellosis incidence in Kenya
Tropical Medicine and Infectious Disease, 2025
A strong example of integrated surveillance and time-series epidemiology across health systems.
Endemic epidemiology of porcine epidemic diarrhea virus in the United States
Transboundary and Emerging Diseases, 2024
Characterizes post-emergence disease dynamics in an endemic production system.
Unveiling invisible farm-to-farm PRRSV transmission links and routes through transmission tree and network analysis
Evolutionary Applications, 2023
Integrates transmission-tree inference and network analysis to reveal otherwise hidden epidemiologic connectivity.
2. Genomics, Evolution & Predictive Immunology
Genomic epidemiology, phylodynamics, pathogen evolution, antigenic relationships, and computational immunology
Representative publications:
Translating viral genetic data to PRRSV-2 cross-neutralization using machine learning
Frontiers in Immunology, 2026
Uses viral genetic information and machine learning to predict antigenic phenotype and cross-neutralization.
An update on the phylogeography and dynamics of pool 4 FMDV spread in East and Horn of Africa
Virus Evolution, 2025
Maps the evolutionary and geographic dynamics of FMDV circulation across East and the Horn of Africa.
Machine learning approaches for forecasting r1-based protective interactions among FMD virus variants
PLOS Computational Biology, 2025
Connects viral sequence information with predicted cross-protection to support more data-driven vaccine matching.
Experimental evidence of vaccine-driven evolution of PRRSV-2
Virus Evolution, 2025
Examines how immune and vaccine pressure may shape viral evolutionary trajectories.
Ecological and evolutionary dynamics of multi-strain viruses
Nature Ecology & Evolution, 2022
A broader conceptual study of how ecological and evolutionary processes shape multi-strain viral systems.
3. Population health, behavior & resilient systems
Genomic epidemiology, phylodynamics, pathogen evolution, antigenic relationships, and computational immunology
Representative publications:
Socio-ecological factors associated with becoming street-connected among working and homeless children and youth in Namibia
Global Public Health, 2026
Demonstrates the broader population-health side of PEDIL through socio-ecological risk analysis.
Barriers and breakthroughs in U.S. swine biosecurity: A key informant exploration of the role of human behavior in enhanced biosecurity compliance
Transboundary and Emerging Diseases, 2026
Shows how behavioral and implementation factors shape real-world biosecurity adoption.
Pastoralists utilization and preferences for stakeholders and methods in livestock disease reporting and response in northern Kenya
BMC Veterinary Research, 2026
Examines how communities engage with surveillance and response systems and which reporting pathways they prefer.
Assessment of roles and challenges of community health workers in pandemic preparedness using lessons from the COVID-19 outbreak in rural Uganda
Discover Public Health, 2026
Extends the portfolio into health-system preparedness, frontline capacity, and community response.
Education and Economic Factors Shape Clusters of Biosecurity Beliefs and Practices: Insights from an Exploratory Survey of Midwest U.S. Swine Producers
Pathogens, 2025
Explores how socioeconomic and behavioral factors shape biosecurity beliefs and practices.
Research Translation & Outreach
Understanding PRRSV Cross-Protection & Immune Stimulation
Swine Doc Pod with Carthage
A discussion of how viral variation, immunity, and predictive approaches can inform better decisions for PRRSV control.
Recent Publications
Nashandi NJC, Makau DN, Cho M, Buko EO, Lightfoot, E. Socio-ecological factors associated with becoming street-connected among working and homeless children and youth in Namibia. Glob Public Health 2026, VOL. 21, NO. 1, 2700820
Pamornchainavakul N, Huang J, Paploski I, Makau DN, Ferreira CP, Krishna VD, Schroeder DC, Cheeran MC-J and VanderWaal K. Translating viral genetic data to PRRSV-2 cross-neutralization using machine learning. Front. Immunol. 17:1875393
Gelalcha B, Chepkwony M, Corzo C, Yoder C, Perez A, Perez Aguirreburualde MS, Makau DN, Mahero MW. Barriers and Breakthroughs in U.S. Swine Biosecurity: A Key Informant Exploration of the Role of Human Behavior in Enhanced Biosecurity Compliance. Transbound Emerg Dis. 2 026; 2026:5537668
Sentamu DN, Arasio RL, Makau DN, Onono JO. Pastoralists utilization and preferences for stakeholders and methods in livestock disease reporting and response in northern Kenya: a participatory study. BMC Vet Res. 2026
Kungu JM, Galiwango JB, Makau DN, Odoi A, Namayanja J, Oposhia J, Nizeyi JB. Assessment of roles and challenges of community health workers in pandemic preparedness using lessons from the COVID-19 outbreak in rural Uganda. Discov Public Health.
Kahariri S, Thomas LF, Bett B, Mureithi M, Makori A, Samuel K, Makau DN, Mutono N, Thumbi SM. Synergizing human and animal health surveillance systems: A time series analysis of brucellosis incidence in Kenya. Trop. Med. Infect. Dis.
Gunasekera U, Mohamed Fazi MA, Bartels C, Punyapornwithaya V, Perez A, VanderWaal K, Makau DN. Optimizing risk-based disease control strategies through network analysis: Case insights from FMD in Sri Lanka. Prev Vet Med.
Gelalcha B, Chepkwony M, Corzo C, Yoder C, Perez A, Perez Aguirreburualde MS, Makau DN, Mahero MW. Education and Economic Factors Shape Clusters of Biosecurity Beliefs and Practices: Insights from an Exploratory Survey of Midwest U.S. Swine Producers. Pathog.
Makau DN, Artz J, VanderWaal K. An update on the phylogeography and dynamics of pool 4 FMDV spread in East and Horn of Africa. Virus Evol.
Makau DN, Artz J, VanderWaal K. Machine learning approaches for forecasting r1-based protective interactions among FMD virus variants. Plos Comp Bio.
Chepkwony M, Makau DN, Yoder C, Corzo CA, Culhane MR, Perez AM, Pérez Aguirreburualde MS, Nault AJ, Mahero MW. A scoping review of knowledge, attitudes, and practices on biosecurity in swine production farms in North America. Front Vet Sci.
Chepkwony MC, Yoder C, Culhane MR, Aguirreburualde MSP, Perez AM, Corzo CA, Makau DN, Mahero MW. Beliefs, behaviors, and practices of farm biosecurity in the Midwestern U.S. swine operations. Animals (Basel).
Pamornchainavakul N, Paploski I, Makau DN, Baker J, Huang J, Ferreira C, Corzo C, Rovira A, Cheeran M, Lycett S, Doeschl-Wilson A, Schroeder D, VanderWaal K. Experimental evidence of vaccine-driven evolution of PRRSV-2. Virus Evol.
Cho M, Koo D, Rief R, Makau DN. Patterns of early risk factors for juvenile justice outcomes in youth with high-incidence disabilities. Crime and Delinquency.
VanderWaal K, Pamornchainavakul N, Kikuti M, Zhang J, Zeller M, Trevisan G, Rossow S, Schwartz M, Linhares D, Holtkamp D, da Silva J, Corzo C, Baker J, Anderson T, Makau DN, Paploski I. PRRSV-2 variant classification: a dynamic nomenclature for enhanced monitoring and surveillance. mSphere.
Dinede G., Keba A., Amenu K., Makau DN and Grace D. Enhancing evidence-informed decision-making in Ethiopia's animal health sector with Global Burden of Animal Diseases support: Game learning of evidence ecosystem. (Nairobi, Kenya: ILRI).
Sentamu DN, Arasio RL, Akala H, Makau DN, Wasonga OV, Onono JO. Stakeholder analysis and their roles in livestock disease reporting and response in Northern Kenya. Pastoralism.
Makau DN, VanderWaal K, Kikuti M, Picasso-Risso C, Geary E, Corzo CA. Endemic epidemiology of porcine epidemic diarrhea virus in the United States. Transbound Emerg Dis.
Schultze M, Kincheloe JM, Makau DN, Knauer W, Wells SJ. Assessment of use of biosecurity practices to prevent chronic wasting disease in Minnesota cervid herds. Prev Vet Med.
Paploski IAD, Kiesel G, Makau DN, Pamornchainavakul N, Baker JP, Kikuti M, Corzo CA, VanderWaal K. Weathering the storm: extreme weather events and their association with PED and PRRS occurrence. Vet Microbiol.
Kikuti M, Melini CM, Yue X, Paploski IAD, Pamornchainavakul N, Baker J, Makau DN, VanderWaal K, Maschhoff A, Henness K, Drebes D, Corzo CA. Monitoring of porcine reproductive and respiratory syndrome virus variant emergence. Vet Microbiol.